Simparica Trio is a veterinary medicinal product designed to protect dogs from parasites. Developed by Zoetis, this monthly chewable tablet has been formulated to provide broad-spectrum protection against fleas, ticks, and internal worms, as well as the deadly heartworm disease.
Components and Mechanism of Action:
Simparica Trio is a combination of three active ingredients:
- Sarolaner – An ectoparasiticide, sarolaner is responsible for killing fleas and ticks. It works by blocking the neurotransmitter gamma-aminobutyric acid (GABA) receptor and glutamate receptor function, leading to paralysis and death of these ectoparasites.
- Moxidectin – An endoparasiticide, moxidectin is effective against heartworms and some internal worms like roundworms. It affects the parasite’s nerve transmission, leading to paralysis and subsequent death.
- Pyrantel – Another endoparasiticide, pyrantel targets roundworms and hookworms. It causes paralysis in these worms by acting on their nicotinic acetylcholine receptors.
Efficacy:
Simparica Trio offers broad-spectrum protection:
- Fleas: Begins killing fleas within 4 hours and keeps them away for a full month.
- Ticks: Provides protection against various tick species like the lone star tick, Gulf Coast tick, American dog tick, and the brown dog tick.
- Heartworm Disease: Acts as a preventive measure against Dirofilaria Immitis, the parasite responsible for heartworm disease.
- Internal Worms: Effective against roundworms and hookworms, common intestinal parasites in dogs.
![Simparica Trio](https://happypetville.com/wp-content/uploads/2023/09/Simparica-Trio.jpg)
Administration:
Simparica Trio is administered orally as a monthly chewable. It’s crucial to administer it every month without missing doses, especially for consistent heartworm disease prevention. The dosage varies depending on the dog’s weight, so it’s essential to consult a veterinarian to determine the correct tablet strength.
Simparica Trio Table
Parameter | Description |
---|---|
Product Name | Simparica Trio |
Active Ingredients | – Sarolaner |
– Moxidectin | |
– Pyrantel | |
Indications | – Flea and tick prevention and treatment |
– Treatment and prevention of heartworm disease | |
– Treatment of roundworms and hookworms | |
Species | Dogs |
Formulation | Chewable tablets |
Dosing Frequency | Once a month |
Age for Use | For puppies 8 weeks of age and older |
Weight Classes | Various, such as: |
– 2.8-5.5 lbs | |
– 5.6-11.0 lbs | |
– 11.1-22.0 lbs | |
– … (and so on) | |
Contraindications | Do not use in dogs with known hypersensitivity to any of the ingredients. |
Side Effects | – Vomiting |
– Diarrhea | |
– Decreased appetite | |
– Lethargy | |
Storage | Store at or below 30°C (86°F). |
Manufacturer | Zoetis |
Please remember that the above details are based on general knowledge. Before using any medication, always refer to the product’s label or package insert and consult with a veterinarian.
Side Effects:
As with many medications, there are potential side effects, although the majority of dogs tolerate Simparica Trio well. Some possible side effects include:
- Vomiting
- Diarrhea
- Lethargy
- Decreased appetite
- Increased thirst
It’s essential to observe your dog for any unusual behavior or symptoms after administering the tablet. If any adverse reactions are noticed, it’s crucial to consult a veterinarian immediately.
![Simparica Trio](https://happypetville.com/wp-content/uploads/2023/09/Simparica-Trio-1.jpg)
Contraindications:
Simparica Trio is formulated for dogs, and thus, it should not be administered to other animals or humans. It is also not recommended for puppies less than eight weeks old or those weighing less than 2.8 lbs (1.3 kg).
Simparica Trio offers a convenient solution for dog owners looking to protect their pets from a range of external and internal parasites. With its broad-spectrum efficacy, it reduces the need for multiple medications and ensures that dogs remain safe from harmful parasites and the diseases they transmit. However, as with all medications, it’s essential to administer it responsibly, follow dosage recommendations, and consult with a veterinarian regularly for the best results.
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